Pubdate: Tue, 04 Aug 1998 Date: 04/08/1998 Source: Toronto Star (Canada) Author: Alex Gunz Rosie DiManno is right in saying that it took us a "hundred years" to "realize that perhaps depression is physiological in nature for many people" (Column, April 1). But it took us a few decades longer to realize that it also has strong psychological components. Biology merely disposes one to it. She is wrong in her claim that "new, anti-depressants can almost immediately accomplish what therapy could not." Anti-depressant medications usually take several weeks to work, and in clinical trials, have success rates similar to those for verbal therapy. In fact, cognitive therapy seems to produce lower relapse rates than drug treatments. DiManno further suggests that we conduct research to find new drugs in order to cure those "predisposed to drug addiction." Research has shown little support for the existence of an "addictive personality," but even were we to accept that such a thing existed, is it really a good idea to preemptively put healthy people on drugs to stop them using drugs? Alex Gunz Etobicoke